Moscow, June 9 (SANA) Russian researchers have developed innovative approaches to diagnosing and treating glioma, one of the most common and aggressive brain tumours, according to Russia Today.
Russia Today website published on Tuesday that scientists from the Institute of Higher Nervous Activity and Neurophysiology of the Russian Academy of Sciences worked on the project in cooperation with the Burdenko National Medical Research Centre for Neurosurgery and Lomonosov Moscow State University.
The team developed a diagnostic method based on positron emission tomography (PET) and computed tomography (CT) using a new radiopharmaceutical compound built on radioactive aptamer molecules. Researchers said the molecules can selectively accumulate in tumour tissue, helping improve the accuracy of tumour detection during diagnostic examinations.
Scientists have also developed therapeutic approaches that link aptamer molecules with anti-cancer agents to enhance their direct delivery to glioma cells. Additional compounds are being studied for their potential to increase tumour sensitivity to radiotherapy while limiting the spread of cancer cells into healthy tissue.
The researchers are also testing another experimental strategy based on reprogramming cancer cells through a combination of specialized molecules to transform them into cells resembling healthy, non-dividing brain cells.
Professor Galina Pavlova said preliminary results appear promising, adding that efforts are currently underway to secure patents and prepare the new methods for preclinical trials.
Glioma is among the most widespread malignant brain tumours and is characterized by rapid growth and infiltration into surrounding brain tissue, making treatment particularly challenging and driving efforts to develop more precise and effective diagnostic and therapeutic tools.
R.H/Abd
