Moscow, June 22 (SANA) A team of scientists from Omsk State University, in collaboration with researchers from the Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, has developed a new method for synthesizing biologically active chemical compounds that could contribute to the development of drugs for breast cancer, diabetes and hypertension, Russian News Agency (TASS) reported Monday.
The researchers successfully produced derivatives of pyridin-2-one compounds—substances already used in a number of medications for various diseases—through a chemical reaction in a superbasic medium that allows control over the properties of the resulting molecules, according to the report .
The new technique enabled the production of 4-arylpyridin-2-one compounds with yields as high as 97 to 98 percent, with the ability to modify their molecular structure to develop specific therapeutic properties . The study was supported by a grant from the Russian Science Foundation .
Promising results against breast cancer cells
Laboratory tests on human breast cancer cells (BT474) showed that some of the synthesized compounds successfully inhibited cancer cell growth and induced cell death, while control samples remained unaffected .
“These developments allow us to expand the arsenal of compounds for studying biological activity. This is fundamental knowledge that could become the basis for the design of new drugs,” said Vladislav Shuvalov, associate professor of organic and analytical chemistry at Omsk State University, who led the project, according to the report .
Pyridin-2-one derivatives are known for their wide range of pharmacological effects, including antidiabetic, anticonvulsant, anticancer, antiviral, antifungal and antibacterial properties, according to scientific literature . Research into such compounds continues globally, with studies demonstrating their potential as antidiabetic agents through α-glucosidase inhibitory activity .
The results represent a step toward expanding the range of compounds available for biological study and could form the basis for future research aimed at developing new drugs for serious diseases.
KhA
